Cheap flights from San Francisco to South America

Travel > South America

Check our current prices for flights from San Francisco to South America. Please note that we also give you historical search data for this city connection. These are all airfares that people found in the past, in order to find more current flight information from San Francisco to South America, you will need to run a search below.

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From $788 / RT details

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Cheap Guayaquil airfares from $788/RT are provided by Cheapoair.com. Outbound flight is leaving on 04/23/2025, 02:10 pm from San Francisco Intl (SFO) airport and arrives at Guayaquil Bolivar (GYE) at 01:55 am. The flight time is 11 hours and 45 minutes. The Returning flight departes on 05/07/2025, 03:50 am (other return dates are also available). Date posted: 21 Dec 2024

Price evolution for flights From San Francisco To South America

Recent Deals on Flights from San Francisco to South America:Roundtrip / Oneway

• $788 Avianca Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/23/2025	02:10 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	03:50 am

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• $810 Avianca Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/22/2025	02:20 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	03:15 am

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• $820 Lan Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/22/2025	11:55 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	08:25 pm

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• $879 Multiple Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	04/23/2025	08:10 am
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	05/07/2025	03:50 am

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• $977 Avianca Airlines 

  From	To	Departure	Time
  San Francisco, CA (SFO)	Guayaquil, EC (GYE)	07/01/2025	02:20 pm
  Guayaquil, EC (GYE)	San Francisco, CA (SFO)	07/15/2025	06:30 pm

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• We are sorry but currently there are no oneway offers for flights from San Francisco to South America.
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