Cheap flights from San Francisco to South America
Travel > South America
Travel tip: I was there 5 years ago, the people is werry friendly, they make you part of their family, is so hard to forget people like them!Check our current prices for flights from San Francisco to South America. Please note that we also give you historical search data for this city connection. These are all airfares that people found in the past, in order to find more current flight information from San Francisco to South America, you will need to run a search below.
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Cheap Guayaquil airfares from $788/RT are provided by Cheapoair.com. Outbound flight is leaving on 04/23/2025, 02:10 pm from San Francisco Intl (SFO) airport and arrives at Guayaquil Bolivar (GYE) at 01:55 am. The flight time is 11 hours and 45 minutes. The Returning flight departes on 05/07/2025, 03:50 am (other return dates are also available). Date posted: 21 Dec 2024
Price evolution for flights From San Francisco To South America

Recent Deals on Flights from San Francisco to South America:Roundtrip / Oneway
- $788
Avianca Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 04/23/2025 02:10 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 05/07/2025 03:50 am - $810
Avianca Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 04/22/2025 02:20 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 05/07/2025 03:15 am - $820
Lan Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 04/22/2025 11:55 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 05/07/2025 08:25 pm - $879
Multiple Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 04/23/2025 08:10 am Guayaquil, EC (GYE) San Francisco, CA (SFO) 05/07/2025 03:50 am - $977
Avianca Airlines
cheapoair.com check priceFrom To Departure Time San Francisco, CA (SFO) Guayaquil, EC (GYE) 07/01/2025 02:20 pm Guayaquil, EC (GYE) San Francisco, CA (SFO) 07/15/2025 06:30 pm - We are sorry but currently there are no oneway offers for flights from San Francisco to South America.
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