Cheap flights from Pennsylvania to Santa Cruz

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The history of Santa Cruz begins with a colonial settlement, as is the case with most South American cities. Spanish conquistador Nulfo de Chavez was the first to get there and to found a settlement on February 26, 1561. He named the city Santa Cruz de la Sierra (“Holy Cross of the Hills”) and continued his exploration through the jungles and rainforests in the territory. He also founded Buenos Aires and Asuncion, and the three cities grew to become important economical and... (read more in our Santa Cruz History)

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Philadelphia 

Check our newest flight offers to Santa Cruz:

  • $1215Copa Air flight Copa Air 
    FromToDepartureTime
    Philadelphia, PA (PHL)Santa Cruz, BO (VVI)10/11/201706:15 am
    Santa Cruz, BO (VVI)Philadelphia, PA (PHL)10/18/201702:18 am
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  • $1381Copa Air flight Copa Air 
    FromToDepartureTime
    Philadelphia, PA (PHL)Santa Cruz, BO (VVI)01/17/201809:55 am
    Santa Cruz, BO (VVI)Philadelphia, PA (PHL)01/30/201802:18 am
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  • $1470Copa Air flight Copa Air 
    FromToDepartureTime
    Philadelphia, PA (PHL)Santa Cruz, BO (VVI)08/30/201706:15 am
    Santa Cruz, BO (VVI)Philadelphia, PA (PHL)09/13/201702:18 am
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  • $1674Multiple Airlines flight Multiple Airlines 
    FromToDepartureTime
    Philadelphia, PA (PHL)Santa Cruz, BO (VVI)01/17/201806:05 am
    Santa Cruz, BO (VVI)Philadelphia, PA (PHL)01/30/201807:25 am
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